David Jaffe, PhD

Professor

Research in Dr. Jaffe's lab focuses on how individual neurons and networks of neurons process information. Their work primarily focuses on the hippocampal formation, a region of the brain important for the acquisition and consolidation of declarative information (i.e. facts and events) and one that is impacted early in Alzheimer's disease. Using a combination of electrophysiological, optogenetic, imaging, and computational approaches, the lab is currently studying how communication from the cortex is filtered through the dentate gyrus on its way into the hippocampus, and how this impacts mechanisms associated with the replay of newly encoded information during memory consolidation. The lab is also investigating how this circuit is involved in seizures and the development of epilepsy, and how seizure-induced changes in membrane ion channels (i.e. channelopathies) contribute to epileptogenesis. A second area of interest is how pain information is regulated by the dorsal root ganglion.

Email